DM - Degenerative myelopathy is an inherited neurologic disorder of dogs characterized by gradual muscle wasting and loss of coordination. It normally begins in the hind limbs.
German Shepherds are more prone to DM but Rottweilers have been found to be carriers of the disease
Phenotype: Affected dogs usually present clinical signs of disease in adulthood (at least 8 years of age) with gradual muscle wasting and loss of coordination typically beginning in the hind limbs. Disease progression continues until the dog is unable to walk. Small breed dogs tend to progress more slowly. In late stages of the disease, dogs may become incontinent and the forelimbs may be affected. Affected dogs may fully lose the ability to walk 6 months to 2 years after the onset of signs.
Dogs with N/N genoytpe will not have degenerative myelopathy and cannot transmit this variant to their offspring.
Dogs with N/DM genotype will not have degenerative myelopathy, but are carriers. They will transmit this variant to 50% of their offspring. Matings between two carriers are predicted to produce 25% degenerative myelopathy-affected puppies.
Dogs with DM/DM may have degenerative myelopathy, a disabling condition, and will transmit this variant to all of their offspring.